Covid-19 Research Hub

1. The Study, Explained

Washington University and several community partners are working together to expand and improve equitable access to Long COVID care in the St. Louis and surrounding rural region. A key goal of the project is to support primary care teams with practical clinical resources (e.g., simple management algorithms, note templates, regional referral instructions) and efficient educational materials (e.g., Show-Me ECHOs, website of succinct and clinically relevant evidence updates).

2. Why does this study matter?

Long COVID is impacting many individuals and families and yet there are no standard methods for identifying, diagnosing, and treating this condition. New information and research continues to emerge and both patients and providers need to be involved in setting priorities and identifying potential solutions.

3. What happens during the study?

Every 6 months, the project team will recruit healthcare providers (defined broadly) who have seen patients with Long COVID in the past 6 months and recruit patients who have been seen by a provider, at least in part due to, their Long COVID symptoms.

Participants will be asked to complete brief, one-time surveys to share their experiences and feedback regarding Long COVID care.

Surveys will take about 10-15 minutes to complete and participants will receive a $25 gift card for their time.

4. How long should the participant expect to be involved?

After taking the one-time survey, participants can be done with the study.  If interested, participants can provide their contact information (name, phone number, email address) to receive invitations to participate in future surveys or interviews for this project.

5. Take the patient experience survey:

Link to patient online survey: https://redcap.link/lcpatient

1. The Study, Explained

Researchers at Washington University School of Medicine are conducting a clinical trial testing the medication fluvoxamine as a possible treatment for Long COVID. The trial will test whether using fluvoxamine for Long COVID is safe and improves symptoms.

2. Who can participate?

You may be able to participate if:

• You are 25 years old or older
• You had COVID-19 at least 3 months ago
• Since having COVID-19, you continue to have problems with memory, attention, and concentration

3. What happens during the study? (will there be in-person visits? will there be tests?)

This study involves:

• Participating for 22 weeks.
• Two in-person visits lasting up to 2 hours each. (Those living outside of the St. Louis Metro-area in Missouri or Illinois may be able to complete the study remotely)
• Answering questions about your memory, mood, and concentration throughout the study
• Receiving either fluvoxamine or a placebo (sugar pill)
• Up to $100 provided for your time

4. How can I get more information?

Please contact Angie or Aris at 314-747-8906.

email arisperez@wustl.edu or stevens.a@wustl.edu.

visit https://redcap.link/LongCovid

1. The Study, Explained

Persistent smell distortion (parosmia) due to COVID-19 is common! Stellate ganglion block (SGB) is an office-based procedure that has been proposed for treatment of smell distortions. We are recruiting adults for a study of the effectiveness of SGB as a treatment for parosmia due to COVID-19.

2. Who can participate?

You may be able to participate if:

• You are age 18 to 70 living in the USA
• You have computer access and an email address
• You have persistent COVID-related parosmia

3. What happens during the study? (will there be in-person visits? will there be tests?)

This study involves:

• In-person visit to assess smell loss and, if eligible, receive either
  the active or placebo SGB procedure
• Two virtual visits, requiring only internet access

4. How can I get more information?

To participate, please email: otooutcomes@wustl.edu with the subject line “SGB Study”.

For any questions, please contact Clinical Research Outcomes Office at 314-454-2197.

Principle Investigator: Dr. Nyssa Farrell

1. The Study, Explained

Researchers are studying a possible treatment for adults who have Long COVID, which is when a person is sick months after getting COVID. We want to learn if a study drug can reduce ongoing symptoms from the virus that causes COVID.

This study is a placebo controlled trial of Paxlovid, administered for 25 days, for the treatment of COVID-19 related exercise intolerance, autonomic dysfunction and cognitive dysfunction. Patients will be randomized to treatment or study arm and followed for 6 months.

This study is a part of the NIH’s(National Institutes of Health) RECOVER (Researching COVID to Enhance Recovery) program. VITAL stands for Viral persistence and reactivation, and immune dysregulation.

2. Who can participate?

You may be a good fit for this study if:

• You are an adult who has had COVID
• You do not have an active COVID infection
• You still have 1 or more of these symptoms
  • Exhaustion or low energy that interferes with daily activities
  • Trouble thinking clearly or brain fog
  • Dizziness, fast heart rate, shortness of breath, upset stomach or other changes in body functions that happen automatically

3. What happens during the study? (will there be in-person visits? will there be tests?)

If you decide to take part your participation should last about 6 months.

You would:

• Visit the clinic 4 to 5 times to complete surveys, lab test, and physical ability and/or brain function tests
• Take a study drug, provided at no cost
• Answer follow-up surveys online or by phone
• Get paid for your time

4. How can I get more information?

Contact the study team: 314-996-3105 or allergy.research@wustl.edu.

Learn more at trials.recovercovid.org/vital

Health insurance is NOT required.

1. The Study, Explained

iHeard systematically monitors and responds to health information that is circulating in the St. Louis community. Every week, we send a 3-minute survey to a panel of about 200 community members asking what health information they have heard in the last 7 days. We analyze their responses, identify priority information needs in the community, and respond with accurate information for community members and organizations to share.

2. Why does this study matter?

iHeard helps spread timely, accurate information about high-priority local health issues in a coordinated way across a community. Its goal is to increase health knowledge and build trust in health science. Community panel members make their voices heard and help to make a difference in their community by building community health knowledge.

3. What happens during the study? (will there be in-person visits? will there be tests?)

Participants who meet eligibility criteria respond to a 3-minute weekly mobile phone survey. Each survey will remain open for 48 hours. Participants will receive $5 per survey completed.

4. How long should the participant expect to be involved?

We invite participants to be on the panel for one year. Community panel members can opt-out at any time. Participation in this project is completely voluntary.

1. The Study, Explained

Our team is developing and sharing latest information and news about Long COVID. Information may include short summaries of the latest research findings, Long COVID resources, general Long COVID news, and more. We would like to enroll a panel of 50 African American adults to receive this information and share their thoughts to help us improve our materials.

2. Why does this study matter?

Long COVID is impacting families and communities yet trusted information about the new condition can be hard to find. Doctors and medical researchers continue to look into the causes of Long COVID, ways to diagnosis Long COVID, and treatments for Long COVID. As new information emerges knowledge gaps can arise. These knowledge gaps can particularly impact low-income minority communities and African Americans have been especially impacted by COVID. Our studies seeks to close information gaps around Long COVID to help people to find accurate information and useful resources.

3. What happens during the study?

To enroll, panel members will complete a brief 15-25 minute online survey about their Long COVID experiences. Panel members will then receive weekly messages for 4 months and have an opportunity to give their immediate feedback after each message through weekly mini-surveys. After 4 months, panel members will complete one final online survey about their Long COVID knowledge and experiences.

Panel members will receive a $25 gift card for the enrollment survey and can earn a $25 bonus for completing optional additional questions at the end of the survey. Panel members will also receive a $25 gift card for the final survey and can earn a $25 bonus for completing at least half of weekly mini-surveys. Participants can earn a total of up to $100 in gift cards by participating.

4. How long should the participant expect to be involved?

After taking the enrollment survey, participants should expect to receive messages every week for about 4 months and respond to one final survey at the end of the study period.